A pathway has been defined linking cell cycle inhibitor p27Kip1 to the inhibition of cyclin-dependent kinase 2 and its phosphorylation of transcription factor Smad3 in the induction of in vivo tolerance.
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Rudd, C. Cell cycle 'check points' T cell anergy. Nat Immunol 7, 1130–1132 (2006). https://doi.org/10.1038/ni1106-1130
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DOI: https://doi.org/10.1038/ni1106-1130
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