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TH-17: a giant step from TH1 and TH2

CD4+ T cells have been classically separated into two dominant effector populations: T helper types 1 and 2. Two new studies suggest that T cells producing interleukin 17 constitute a previously unknown lineage of CD4+ T cells.

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Figure 1: Development of IL-17-producing effector CD4+ T cells (TH-17) by IL-23 is inhibited by IFN-γ and IL-4.

Katie Ris


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Wynn, T. TH-17: a giant step from TH1 and TH2. Nat Immunol 6, 1069–1070 (2005).

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