Are dendritic cells end cells?

Mature dendritic cells are considered terminally differentiated. However, this dogma is challenged by data showing culture-generated mature dendritic cells can further differentiate under the influence of stromal cells.

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Figure 1: A DC isolated from steady-state mouse lymphoid tissue.

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Shortman, K., Wu, L. Are dendritic cells end cells?. Nat Immunol 5, 1105–1106 (2004). https://doi.org/10.1038/ni1104-1105

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