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When ligand becomes receptor—tolerance via B7 signaling on DCs

CTLA-4–Ig is used to block the costimulation of T cells to interfere with their activation. This reagent may actually be working by provoking DCs to catabolize tryptophan, thereby depriving T cells and contributing to their demise.

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References

  1. 1

    Lenschow, D.J., Walunas, T.L. & Bluestone, J.A. Annu. Rev. Immunol. 14, 233–258 (1996).

  2. 2

    Grohmann, U. et al. Nature Immunol. 3, 1097–1101 (2002).

  3. 3

    Mellor, A.L. & Munn, D.H. Immunol Today 20, 469–473 (1999).

  4. 4

    Steinman, R.M. & Nussenzweig, M.C. Proc. Natl. Acad. Sci. USA 99, 351–358 (2002).

  5. 5

    Salomon, B. & Bluestone, J.A. Annu. Rev. Immunol. 19, 225–252 (2001).

  6. 6

    Collins, A.V. et al. Immunity 17, 201–210 (2002).

  7. 7

    Mellor, A.L., Keskin, D.B., Johnson, T., Chandler, P. & Munn, D.H. J. Immunol. 168, 3771–3776 (2002).

  8. 8

    Munn, D.H. et al. Science 297, 1867–1870 (2002).

  9. 9

    Kishimoto, K. et al. J. Clin. Invest. 109, 1471–1479 (2002).

  10. 10

    Serreze, D.V. et al. J. Immunol. 166, 1352–1359 (2001).

  11. 11

    Mandelbrot, D.A. et al. J. Clin. Invest. 107, 881–887 (2001).

  12. 12

    Kaufman, K.A. et al. Molec. Hum. Reprod. 5, 84–87 (1999).

  13. 13

    Schwarz, A. et al. J. Immunol. 165, 1824–1831 (2000).

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Correspondence to Jeffrey A. Bluestone.

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Figure 1: Model of tolerance induction by B7-dependent signaling in DCs.

K. R.