Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

When ligand becomes receptor—tolerance via B7 signaling on DCs

CTLA-4–Ig is used to block the costimulation of T cells to interfere with their activation. This reagent may actually be working by provoking DCs to catabolize tryptophan, thereby depriving T cells and contributing to their demise.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Model of tolerance induction by B7-dependent signaling in DCs.

K. R.

References

  1. Lenschow, D.J., Walunas, T.L. & Bluestone, J.A. Annu. Rev. Immunol. 14, 233–258 (1996).

    CAS  Article  PubMed  Google Scholar 

  2. Grohmann, U. et al. Nature Immunol. 3, 1097–1101 (2002).

    CAS  Article  Google Scholar 

  3. Mellor, A.L. & Munn, D.H. Immunol Today 20, 469–473 (1999).

    CAS  Article  PubMed  Google Scholar 

  4. Steinman, R.M. & Nussenzweig, M.C. Proc. Natl. Acad. Sci. USA 99, 351–358 (2002).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  5. Salomon, B. & Bluestone, J.A. Annu. Rev. Immunol. 19, 225–252 (2001).

    CAS  Article  PubMed  Google Scholar 

  6. Collins, A.V. et al. Immunity 17, 201–210 (2002).

    CAS  Article  PubMed  Google Scholar 

  7. Mellor, A.L., Keskin, D.B., Johnson, T., Chandler, P. & Munn, D.H. J. Immunol. 168, 3771–3776 (2002).

    CAS  Article  PubMed  Google Scholar 

  8. Munn, D.H. et al. Science 297, 1867–1870 (2002).

    CAS  Article  PubMed  Google Scholar 

  9. Kishimoto, K. et al. J. Clin. Invest. 109, 1471–1479 (2002).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  10. Serreze, D.V. et al. J. Immunol. 166, 1352–1359 (2001).

    CAS  Article  PubMed  Google Scholar 

  11. Mandelbrot, D.A. et al. J. Clin. Invest. 107, 881–887 (2001).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  12. Kaufman, K.A. et al. Molec. Hum. Reprod. 5, 84–87 (1999).

    CAS  Article  PubMed  Google Scholar 

  13. Schwarz, A. et al. J. Immunol. 165, 1824–1831 (2000).

    CAS  Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jeffrey A. Bluestone.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Finger, E., Bluestone, J. When ligand becomes receptor—tolerance via B7 signaling on DCs. Nat Immunol 3, 1056–1057 (2002). https://doi.org/10.1038/ni1102-1056

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni1102-1056

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing