Immunity or tolerance? That is the question for dendritic cells

The “two-signal” model proposes that immature DCs that deliver signal 1 in the absence of signal 2 cross-tolerize CD8+ T cells. New evidence shows that mature DCs are required for both cross-tolerance and cross-priming.

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Figure 1: A maturing DC, captured after exit from mouse ear skin.

Jose Villadangos

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Shortman, K., Heath, W. Immunity or tolerance? That is the question for dendritic cells. Nat Immunol 2, 988–989 (2001) doi:10.1038/ni1101-988

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