Lymphocyte memory—is there a requirement for the continual presence of antigen or not? In a recent issue of Nature an elegant series of genetic manipulations from Maruyama et al. makes a strong case for the persistence of B cell memory in the absence of antigen.
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Kelsoe, G. Remembrance of things past. Nat Immunol 1, 375–376 (2000). https://doi.org/10.1038/80811
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DOI: https://doi.org/10.1038/80811