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Remembrance of things past

Lymphocyte memory—is there a requirement for the continual presence of antigen or not? In a recent issue of Nature an elegant series of genetic manipulations from Maruyama et al. makes a strong case for the persistence of B cell memory in the absence of antigen.

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Figure 1: (a) VNP/VPEinv Mx-cre knock-in mice carry VNP and VPEinv Igh alleles and the IFN-inducible Mx-cre transgene.

Bob Crimi


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Kelsoe, G. Remembrance of things past. Nat Immunol 1, 375–376 (2000).

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