Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Immunotherapy of human cancer: lessons from mice

Translating mouse models into clinical therapies has never been easy. Immunotherapies for cancer also have to contend with an approval process designed for testing drugs. It may be necessary to consider different endpoints and objectives when evaluating the efficacy of these newer approaches.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Effect of treatment with tumor-derived heat shock protein–peptide complexes on cancers of mice.
Figure 2: Although an array of immunological markers have been examined as potential surrogate markers of antitumor activity in humans and in mice, none have been found suitable.

References

  1. Srivastava, P. K., Ménoret, A., Basu, S., Binder, R. J. & McQuade, K. Immunity 8, 657–665 (1998).

    Article  CAS  Google Scholar 

  2. Srivastava, P. K., Udono, H., Blachere, N. E. & Li, Z. Immunogenetics 39, 93–98 (1994).

    Article  CAS  Google Scholar 

  3. Suto, R. & Srivastava, P. K. Science 269, 1585–1588 (1995).

    Article  CAS  Google Scholar 

  4. Binder, R. J., Han, D. K. & Srivastava, P. K. Nature Immunol. 1, 151–155 (2000).

    Article  CAS  Google Scholar 

  5. Srivastava, P. K. & Das, M. R. Int. J. Cancer 33, 417–422 (1984).

    Article  CAS  Google Scholar 

  6. Srivastava, P. K., DeLeo, A. B. & Old, L. J. Proc. Natl Acad. Sci. USA 83, 3407–3411 (1986).

    Article  CAS  Google Scholar 

  7. Janetzki, S. et al. Int. J. Cancer (in the press, 2000).

  8. Amato, R. J. et al. Abstr.102696. Am. Soc. Clin. Oncol. (2000).

  9. Lewis, J. J. et al. Abstr. 150411. Am. Soc. Clin. Oncol. (1999).

  10. Tamura, Y., Peng, P., Liu, K., Daou, M. & Srivastava, P. K. Science 278, 117–120 (1997).

    Article  CAS  Google Scholar 

  11. Ramarathinam, L. et al. J. Immunol. 155, 5323–5329 (1995).

    CAS  PubMed  Google Scholar 

  12. Huang, A.Y. et al. Proc. Natl Acad. Sci. USA 93, 9730–9735 (1996)

    Article  CAS  Google Scholar 

  13. Marchand, M. et al. Int. J. Cancer 80, 219–230 (1999).

    Article  CAS  Google Scholar 

  14. Rosenberg, S. A. et al. Nature Med. 4, 321–327 (1998).

    Article  CAS  Google Scholar 

  15. Anichini, A. et al. J. Exp. Med. 190, 651–668 (1999).

    Article  CAS  Google Scholar 

  16. Srivastava, P. K. Semin. Immunol. 8, 295–302 (1996).

    Article  CAS  Google Scholar 

  17. Old, L. J. & Chen, Y. T. J. Exp. Med. 187, 1163–1167 (1998).

    Article  CAS  Google Scholar 

  18. DeVita, Jr, V. T., Hellman, S. & Rosenberg, S.A. Cancer Principles and Practice of Oncology. 5th edn. (Lipincott-Raven, Philadelphia, 1997).

    Google Scholar 

  19. Basu, S., Binder, R. J., Suto, R., Anderson, K. M. & Srivastava, P. K. Int. Immunol. 12 (in the press, 2000).

  20. Singh-Jasuja, H. et al. Eur. J. Immunol. 30, 2211–2215 (2000).

    Article  CAS  Google Scholar 

  21. Binder, R. J., Anderson, K. M., Basu, S. & Srivastava, P. K. J. Immunol. (in the press, 2000).

  22. Janetzki, S., Blachere, N. E. & Srivastava, P. K. J. Immunother. 21, 269–276 (1998).

    Article  CAS  Google Scholar 

  23. Janeway, C. A. Cold Spring Harb. Symp. Quant. Biol. 54, 1–13 (1989).

    Article  CAS  Google Scholar 

  24. Wang, X. Y., Repasky, E. A. & Subjeck, J. R. J. Immunol. (in the press, 2000).

  25. Lengauer, C., Kinzler, K. W. & Vogelstein B. Nature 396, 643–649 (1998).

    Article  CAS  Google Scholar 

  26. Wolfel, T. et al. Science 269, 1281–1284 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Srivastava, P. Immunotherapy of human cancer: lessons from mice. Nat Immunol 1, 363–366 (2000). https://doi.org/10.1038/808795

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/808795

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing