Cytosolic DNA sensors have remained poorly defined so far. Two recent studies identify a previously undefined cytosolic DNA-sensing pathway that depends on the RNA polymerase III–mediated conversion of microbial DNA into 5′-triphosphate double-stranded RNA that activates the RNA helicase RIG-I.
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Cao, X. New DNA-sensing pathway feeds RIG-I with RNA. Nat Immunol 10, 1049–1051 (2009). https://doi.org/10.1038/ni1009-1049
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DOI: https://doi.org/10.1038/ni1009-1049
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