Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Two in one: dual function of an invertebrate antigen receptor

Nature Immunology volume 8, pages 1031–1033 (2007)Cite this article

Differential splicing generates thousands of isoforms of the arthropod cell surface receptor Dscam. A new study explains the ability of these receptors to simultaneously generate homophilic and heterophilic interaction surfaces.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Model of Dscam function.

Kim Caesar

References

  1. Cooper, M.D. & Alder, M.N. Cell 124, 815–822 (2006).

    Article  CAS  PubMed  Google Scholar 

  2. Schmucker, D. et al. Cell 101, 671–684 (2000).

    Article  CAS  PubMed  Google Scholar 

  3. Meijers, R. et al. Nature advance online publication 26 August 2007 (doi:10.1038/nature06147).

    Article  CAS  PubMed  Google Scholar 

  4. Wojtowicz, W.M. et al. Cell 118, 619–633 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Watson, F.L. et al. Science 309, 1874–1878 (2005).

    Article  CAS  PubMed  Google Scholar 

  6. Royet, J., Reichhardt, J.M. & Hoffmann, J.A. Curr. Opin. Immunol. 17, 11–17 (2005).

    Article  CAS  PubMed  Google Scholar 

  7. Wood, W. & Jacinto, A. Nat. Rev. Mol. Cell Biol. 8, 542–551 (2007).

    Article  CAS  PubMed  Google Scholar 

  8. Brennan, C.A., Delaney, J.R., Schneider, D.S. & Anderson, K.V. Curr. Biol. 17, 67–72 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Dong, Y., Taylor, H.E. & Dimopoulos, G. PLoS Biol. 4, e229 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Williams, M.J. J. Immunol. 178, 4711–4715 (2007).

    Article  CAS  PubMed  Google Scholar 

  11. Boehm, T. Cell 125, 845–858 (2006).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Thomas Boehm is in the Department of Developmental Immunology, Max-Planck Institute of Immunobiology, D-79108 Freiburg, Germany. boehm@immunbio.mpg.de,

    Thomas Boehm

Authors
  1. Thomas Boehm
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Boehm, T. Two in one: dual function of an invertebrate antigen receptor. Nat Immunol 8, 1031–1033 (2007). https://doi.org/10.1038/ni1007-1031

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni1007-1031

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing