Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Mutations in AID and UNG extend the function of AID

Mutations now reveal fresh clues about the in vivo function of AID. Interactions with other proteins seem to influence subsequent mutation and DNA rearrangement.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: AID and its function in SHM and CSR.

References

  1. Imai, K. et al. Nat. Immunol. 4, 1023–1028 (2003).

    Article  CAS  Google Scholar 

  2. Ta, V.T. et al. Nat. Immunol. 4, 843–848 (2003).

    Article  CAS  Google Scholar 

  3. Barreto, V., Reina-San-Martin, B., Ramero, A.R., McBride, K.M. & Nussenzweig, M.C. Mol. Cell 12, 501–508 (2003).

    Article  CAS  Google Scholar 

  4. Muramatsu, M. et al. Cell 102, 553–563 (2000).

    Article  CAS  Google Scholar 

  5. Bransteitter, R., Pham, P., Scharff, M.D. & Goodman, M.F. Proc. Natl. Acad. Sci. USA 100, 4102–4107 (2003).

    Article  CAS  Google Scholar 

  6. Chaudhuri, J. et al. Nature 422, 726–730 (2003).

    Article  CAS  Google Scholar 

  7. Manis, J.P., Tian, M. & Alt, F.W. Trends Immunol. 23, 31–39 (2002).

    Article  CAS  Google Scholar 

  8. Reina-San-Martin, B. et al. J. Exp. Med. 197, 1767–1778 (2003).

    Article  CAS  Google Scholar 

  9. Rada, C. et al. Curr. Biol. 12, 1748–1755 (2002).

    Article  CAS  Google Scholar 

  10. Pham, P., Bransteitter, R., Petruska, J. & Goodman, M.F. Nature 424, 103–107 (2003).

    Article  CAS  Google Scholar 

  11. Schrader, C.E., Vardo, J. & Stavnezer, J. J. Exp. Med. 197, 1377–1383 (2003).

    Article  CAS  Google Scholar 

  12. Ehrenstein, M.R. & Neuberger, M.S. EMBO J. 18, 3484–3490 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, Z., Woo, C. & Scharff, M. Mutations in AID and UNG extend the function of AID. Nat Immunol 4, 945–946 (2003). https://doi.org/10.1038/ni1003-945

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni1003-945

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing