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A Foxy tango with NFAT

The transcription factor Foxp3 is essential for regulatory T cell function, yet how Foxp3 operates has remained elusive until now.

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Figure 1: The combinatorial association of AP-1 or Foxp3 with NFATc2 determines the outcome of T cell receptor signaling.

Kim Caesar

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Ho, L., Crabtree, G. A Foxy tango with NFAT. Nat Immunol 7, 906–908 (2006). https://doi.org/10.1038/ni0906-906

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