Up the down staircase

  • An Erratum to this article was published on 01 October 2002

NF-κB is important in many biological processes and is activated by ubiquitous protein kinases. However, in T cells, its activation is regulated by a specific set of adapter proteins.

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Figure 1: An exclusive “upstairs” receptor-recruitment and -activation pathway controlling a common “downstairs” NF-κB activation pathway leading from the cytoplasm to the nucleus.

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Wallach, D. Up the down staircase. Nat Immunol 3, 802–803 (2002). https://doi.org/10.1038/ni0902-802

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