Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

Autoimmunity and lymphoma: tribulations of B cells

In early July 2001 a small meeting was held in Baltimore on the associations of lymphomas with autoimmune conditions. Topics ranged from the effects of defective apoptosis to questions of antigen-drive lymphoproliferation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: High-magnification micrographs that compare and contrast florid lymphoepithelial sialadenitis (LESA) and a low-grade extranodal marginal zone lymphoma of mucosal-associated lymphoid tissue (MALT) type in a parotoid gland.

Jerome S. Burk

References

  1. Kaplan, H. S. & Smithers, D. C. Lancet 1–4 (1959).

  2. Conley, C. L. Johns Hopkins Med. J. 149, 101–109 (1981).

    CAS  PubMed  Google Scholar 

  3. Santana, V. & Rose, N. R. Clin. Immunol. Immunopathol. 63, 205–213 (1992).

    Article  CAS  PubMed  Google Scholar 

  4. Mellors, R. C. Int. Rev. Exp. Pathol. 5, 217–219 (1966).

    CAS  Google Scholar 

  5. Kassan, S. S. et al. Ann. Int. Med. 89, 888–892 (1978).

    Article  CAS  PubMed  Google Scholar 

  6. Talal, N. Rheum. Dis. Clin. North America 18, 507–575 (1992).

    CAS  Google Scholar 

  7. Ansell, S. M., Grant, C. S. & Habermann, T. M. Semin. Oncol. 26, 316–323 (1999).

    CAS  PubMed  Google Scholar 

  8. Sokol, R. J., Hewitt, S. & Stamps, B. K. Brit. Med. J. 282, 2023–2026 (1981).

    Article  CAS  Google Scholar 

  9. Abu-Shakra, M., Gladman D. D. & Urowitz, M. B. Arthritis Rheum. 39, 1050–1054 (1996).

    Article  CAS  PubMed  Google Scholar 

  10. Mellemkjær, L. et al. Arthritis Rheum. 40, 761–768 (1997).

    Article  PubMed  Google Scholar 

  11. Mellemkjær, L. et al. Eur. J. Cancer 32, 1753–1757 (1996)

    Article  Google Scholar 

  12. Holmes, G. K. T. et al. Gut 30, 333–338 (1989).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Greten, T. F. et al. Proc. Natl Acad. Sci. USA 95, 7568–7573 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Fleisher, T. A. et al. Clin. Rev. Allergy Immunol. 20, 109–120 (2001).

    Article  CAS  PubMed  Google Scholar 

  15. Straus, S. E. et al. Blood 98, 194–200 (2001).

    Article  CAS  PubMed  Google Scholar 

  16. Sorrentino, D. et al. Gut 38, 837–840 (1996).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Willis, T. G. et al. Cell 96, 35–45 (1999).

    Article  CAS  PubMed  Google Scholar 

  18. Du, M. Q. et al. Blood 95, 3885–3890 (2000).

    CAS  PubMed  Google Scholar 

  19. Bernacchi, E. et al. Exp. Dermatol. 8, 480–486 (1999).

    Article  CAS  PubMed  Google Scholar 

  20. Tsujimoto, Y., Cossman, J., Jaffe, E. & Croce, C. M. Science 228, 1440–1443 (1985).

    Article  CAS  PubMed  Google Scholar 

  21. Damle, R. N. et al. Curr. Top. Microbiol. Immunol. 252, 285–292 (2000).

    CAS  PubMed  Google Scholar 

  22. Mackay, F. et al. J. Exp. Med. 190, 1697–1710 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Cheema, G. S., Roschke, V., Hilbert, D. M. & Stohl, W. Arthritis Rheum. 44, 1313–1319 (2001).

    Article  CAS  PubMed  Google Scholar 

  24. Jacobs, H., Rajewsky, K., Fukita, Y. & Bross, L. Phil. Trans. R. Soc. Lond. B 356, 119–125 (2001).

    Article  CAS  Google Scholar 

  25. Bross, L. et al. Immunity 13, 589–597 (2000).

    Article  CAS  PubMed  Google Scholar 

  26. Desiderio, S. Nature Immunol. 1, 463–464 (2000).

    Article  CAS  Google Scholar 

  27. Burke, J. S. Am. J. Clin. Pathol. 111, 133–143 (1999).

    Google Scholar 

  28. Miklos, J. A., Swerdlow, S. H. & Bahler, D. W. Blood 95, 3878–3884 (2000).

    CAS  PubMed  Google Scholar 

  29. Alizadeh, A. A. et al. Nature 403, 503–511 (2000).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank E. Alexander, T. Waldmann, K. Rajewsky and S. Desiderio for reviewing the manuscript. They thank all the participants in the workshop for so generously sharing their time and data. The workshop was supported by The Johns Hopkins Autoimmune Disease Research Center, The American Autoimmune-Related Disease Association, The Leukemia and Lymphoma Society and The Sjögren's Disease Foundation.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mackay, I., Rose, N. Autoimmunity and lymphoma: tribulations of B cells. Nat Immunol 2, 793–795 (2001). https://doi.org/10.1038/ni0901-793

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0901-793

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing