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Modeling costimulation

Nature Immunology volume 1, pages 194–195 (2000)Cite this article

T cell activation usually requires TCR engagement by antigen and another, costimulatory, signal. Modeling studies now indicate that this second signal may only slightly enhance TCR signaling, but nevertheless results in an exponential increase in cell numbers.

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Figure 1: (a) An updated two-signal model of T cell activation.

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  1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK

    P. Anton van der Merwe

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  1. P. Anton van der Merwe
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van der Merwe, P. Modeling costimulation. Nat Immunol 1, 194–195 (2000). https://doi.org/10.1038/79729

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