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Selecting killers: the line between life and death

Nature Immunologyvolume 1pages192194 (2000) | Download Citation

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How do T cells that are specific for pancreatic islet cell antigens cause diabetes? A recent paper in Nature provides evidence from NOD mice that the killer T cells responsible increase their avidity as the disease progresses—removing the high avidity clones prevents disease.

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Affiliations

  1. Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, 02115, MA, USA

    • Lindsay B. Nicholson
    •  & Vijay K. Kuchroo

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https://doi.org/10.1038/79726

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