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Marriage, divorce, and promiscuity in human B cells

It is becoming more apparent that some B cells do not carry the same antigen receptors throughout their life. B cells that have edited their receptors have now been found in humans as rare cells that accumulate in arthritic joints.

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Figure 1: Differences in H3CDR3 size and shape are illustrated in this comparison of four known antibody structures.

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Schroeder, H., Kirkham, P. Marriage, divorce, and promiscuity in human B cells. Nat Immunol 1, 187–188 (2000). https://doi.org/10.1038/79717

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