Jawless fishes, the 'sister' group of jawed vertebrates, use leucine-rich repeat–containing proteins as antigen receptors. New work shows that the two isotypes of variable lymphocyte receptors are expressed in distinct lymphocyte lineages, which indicates that lymphocytes resembling T cells and B cells are an ancient feature of all vertebrates.
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Boehm, T. One problem, two solutions. Nat Immunol 10, 811–813 (2009). https://doi.org/10.1038/ni0809-811
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DOI: https://doi.org/10.1038/ni0809-811
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