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New insight into the everlasting host-pathogen arms race

Nature Immunology volume 10, pages 808809 (2009) | Download Citation

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New work explains how the interferon-γ-regulated GTPase Irgm1 on phagosomes responds to intracellular signaling and recruits the 'machinery' for fusion with lysosomes. This pathway overlaps a signaling route controlled by bacteria to prevent the fusion of phagosomes with lysosomes.

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Author information

Affiliations

  1. Coenraad Kuijl and Jacques Neefjes are in the Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

    • Coenraad Kuijl
    •  & Jacques Neefjes

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Corresponding author

Correspondence to Jacques Neefjes.

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DOI

https://doi.org/10.1038/ni0809-808

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