New insight into the everlasting host-pathogen arms race

New work explains how the interferon-γ-regulated GTPase Irgm1 on phagosomes responds to intracellular signaling and recruits the 'machinery' for fusion with lysosomes. This pathway overlaps a signaling route controlled by bacteria to prevent the fusion of phagosomes with lysosomes.

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Figure 1: Battle of the GTPases Rab14 and Irgm1.

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Correspondence to Jacques Neefjes.

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Kuijl, C., Neefjes, J. New insight into the everlasting host-pathogen arms race. Nat Immunol 10, 808–809 (2009). https://doi.org/10.1038/ni0809-808

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