Modern cellular and molecular studies have made great progress in characterizing the mechanisms that control immune responses. Now it is time to broaden the present views to accommodate evidence from epitope-specific and other immunoregulatory systems, which were well studied some years ago and are still highly relevant to contemporary work.
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Herzenberg, L. Epitope-specific regulation: the elephant in the bathtub. Nat Immunol 8, 783–786 (2007). https://doi.org/10.1038/ni0807-783
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DOI: https://doi.org/10.1038/ni0807-783