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FOXtrot and RAGtime in B cells

Networks of transcription factors regulate cell fate 'decisions'. The forkhead protein Foxp1 is now identified as a key regulator of B cell development that influences the expression of recombination-activating genes.

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Figure 1: Regulation of B cell differentiation and RAG expression by Foxp1.

Kim Caesar

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Savarese, F., Grosschedl, R. FOXtrot and RAGtime in B cells. Nat Immunol 7, 793–794 (2006). https://doi.org/10.1038/ni0806-793

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