Although γδ T cells were discovered fortuitously more than 20 years ago, their development remains enigmatic. Genetic evidence now suggests that γδ T lymphocytes undergo intrathymic positive selection.
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Bonneville, M. Selection of intraepithelial γδ cells: the Holy GrIEL at last?. Nat Immunol 7, 791–792 (2006). https://doi.org/10.1038/ni0806-791
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DOI: https://doi.org/10.1038/ni0806-791