Rap1 mediates 'inside-out' signaling from the T cell receptor to LFA-1. The discovery of RAPL, a Rap1-binding molecule, helps explain how Rap1 induces T cell adhesion.
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Abraham, R. Rap1 redux. Nat Immunol 4, 725–727 (2003). https://doi.org/10.1038/ni0803-725
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DOI: https://doi.org/10.1038/ni0803-725
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