FcεRI activation of mast cells was thought to be Lyn-dependent. It now appears that FcεRI also uses a Fyn kinase–dependent pathway that is essential for mast cell degranulation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Eiseman, E. & Bolen, J.B. Nature 355, 78–80 (1992).
Nadler, M.J., Matthews, S.A., Turner, H. & Kinet, J.P. Adv. Immunol. 76, 325–355 (2000).
Parravicini, V. et al. Nature Immunol. 3, 741–748 (2002).
Nishizumi, H. & Yamamoto, T. J. Immunol. 158, 2350–2355 (1997).
Kawakami, Y. et al. J. Immunol. 165, 1210–1219 (2000).
Costello, P.S. et al. Oncogene 13, 2595–2605 (1996).
Zhang, J., Berenstein, E.H., Evans, R.L. & Siraganian, R.P. J. Exp. Med. 184, 71–79 (1996).
Gu, H. et al. Nature 412, 186–190 (2001).
Pivniouk, V.I, et al. J. Clin. Invest. 103, 1737–1743 (1999).
Saitoh, S. et al. Immunity 12, 525–535 (2000).
Ozawa, K. et al. J. Biol. Chem. 268, 1749–1756 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nadler, M., Kinet, JP. Uncovering new complexities in mast cell signaling. Nat Immunol 3, 707–708 (2002). https://doi.org/10.1038/ni0802-707
Issue Date:
DOI: https://doi.org/10.1038/ni0802-707
This article is cited by
-
Fyn kinase regulates type II PtdIns 4-kinases in RBL 2H3 cells
Molecular and Cellular Biochemistry (2014)
-
Calcium signaling in immune cells
Nature Immunology (2009)
-
Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release–activated calcium channels
Nature Immunology (2008)
-
Regulation of M2‐type pyruvate kinase mediated by the high‐affinity IgE receptors is required for mast cell degranulation
British Journal of Pharmacology (2008)
-
New targets for allergic rhinitis — a disease of civilization
Nature Reviews Drug Discovery (2003)