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B cell specification from the genome up

Lineage specification and development require a hierarchy of transcription factors. A genome-wide view of transcription factor binding provides new insights into early B lineage development.

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Figure 1: The binding of E2A with different partners across the genome in the pre-pro-B cell–to–pro-B cell transition.

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Correspondence to Ellen V Rothenberg.

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Rothenberg, E. B cell specification from the genome up. Nat Immunol 11, 572–574 (2010). https://doi.org/10.1038/ni0710-572

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