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Successful microarray experimentation can generate enormous amounts of data, potentially very rich but also very unwieldy. Bold outlooks and new methods for data analysis and presentation should yield additional insight into the complexities of the immune system.

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Acknowledgements

We thank D. Laidlaw, J.J. Collins and D. Koller for discussions; E. Hyatt, Q.M. Pham, G. Losyev, R. Saccone and J. Johnson for assistance with mice, cell sorting and microarray processing; and the S+ Listserv members for advice. Supported by the National Institutes of Health (AR046580, AI51530, AI52343, DK60027, DK59658 to C.B. and D.M.) and the William T. Young Chair.

Author information

Affiliations

  1. Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA. cbdm@joslin.harvard.edu

    • Gordon Hyatt
    • , Rachel Melamed
    • , Richard Park
    • , Reuben Seguritan
    • , Catherine Laplace
    • , Laurent Poirot
    • , Silvia Zucchelli
    • , Reinhard Obst
    • , Michael Matos
    • , Emily Venanzi
    • , Ananda Goldrath
    • , Linh Nguyen
    • , John Luckey
    • , Tetsuya Yamagata
    • , Ann Herman
    • , Jonathan Jacobs
    • , Diane Mathis
    •  & Christophe Benoist
  2. Laurent Poirot and Ann Herman are now with the Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.

    • Laurent Poirot
    •  & Ann Herman
  3. Silvia Zucchelli is now with the SISSA-LNM, Area Science Park, Basovizza, 34012 Trieste, Italy.

    • Silvia Zucchelli
  4. Michael Matos is now with Wolfeboro Pediatrics, Wolfeboro, New Hampshire 03894, USA.

    • Michael Matos
  5. Ananda Goldrath is now in the Division of Biology, University of San Diego, La Jolla, California 92093, USA.

    • Ananda Goldrath
  6. Linh Nguyen is now with The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute and Princess Margaret Hospital, Toronto, Canada.

    • Linh Nguyen
  7. Tetsuya Yamagata is now in the Department of Hematology, Dokkyo University School of Medicine, Tochigi-Ken, Japan.

    • Tetsuya Yamagata

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https://doi.org/10.1038/ni0706-686

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