CpG signaling through TLR9 elicits type 1 cytokine production, which can suppress IgE-associated hypersensitivity reactions. CpG also acts directly on B cells by inducing STAT1-independent T-bet expression.
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References
Wild, J.S. & Sur, S. Allergy 56, 365–376 (2001).
Krieg, A.M. Annu. Rev. Immunol. 20, 709–760 (2002).
Liu, N., Ohnishi, N., Lin, N., Akira, S. & Bacon, K.B. Nat. Immunol. 4, 687–693 (2003).
Szabo, S.J. et al. Cell 100, 655–669 (2000).
Finotto, S. et al. Science 295, 336–338 (2002).
Slack, J.H. et al. J. Immunol. 132, 1271–1275 (1984).
Peng, S.L., Szabo, S.J. & Glimcher, L.H. Proc. Natl. Acad. Sci. USA 99, 5545–5550 (2002).
Verthelyi, D., Ishii, K.J., Gursel, M., Takeshita, F. & Klinman, D.M. J. Immunol. 166, 2372–2377 (2001).
Ballas, Z.K., Rasmussen, W.L. & Krieg, A.M. J. Immunol. 157, 1840–1845 (1996).
Lee, Y.L., Fu, C.L., Ye, Y.L. & Chiang, B.L. Scand. J. Immunol. 49, 229–236 (1999).
Leadbetter, E.A. et al. Nature 419, 603–607 (2002).
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Rifkin, I., Marshak-Rothstein, A. T-bet: The Toll-bridge to class-switch recombination?. Nat Immunol 4, 650–652 (2003). https://doi.org/10.1038/ni0703-650
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DOI: https://doi.org/10.1038/ni0703-650
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