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Treg cells meet their limit

Nature Immunology volume 10, pages 565–566 (2009)Cite this article

T cell antigen receptor (TCR)-transgenic models have been enormously influential in studies of T cell development in the thymus, particularly in terms of positive and negative selection. New transgenic mice produced with TCR genes cloned from regulatory T cells show that TCR specificity does 'instruct' regulatory T cell fate, within limits.

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Authors and Affiliations

  1. Department of Laboratory Medicine and Pathology at the University of Minnesota, Minneapolis, Minnesota, USA

    Kristin A Hogquist & Amy E Moran

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  1. Kristin A Hogquist
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  2. Amy E Moran
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Hogquist, K., Moran, A. Treg cells meet their limit. Nat Immunol 10, 565–566 (2009). https://doi.org/10.1038/ni0609-565

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