Toll-like receptors trigger an innate immune response by activating signaling pathways that are dependent on IRAK kinases. According to Kawagoe et al., the least understood IRAK member, IRAK2, is required for the perpetuation of these signals.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules
Scientific Reports Open Access 15 October 2018
-
The kinome of Phytophthora infestans reveals oomycete-specific innovations and links to other taxonomic groups
BMC Genomics Open Access 09 December 2010
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kawai, T. & Akira, S. Semin. Immunol. 19, 24–32 (2007).
Martin, M., Bol, G.F., Eriksson, A., Resch, K. & Brigelius-Flohe, R. Eur. J. Immunol. 24, 1566–1571 (1994).
Janssens, S. & Beyaert, R. Mol. Cell 11, 293–302 (2003).
Kawagoe, T. et al. Nat. Immunol. 9, 684–691 (2008).
Muzio, M., Ni, J., Feng, P. & Dixit, V.M. Science 278, 1612–1615 (1997).
Fitzgerald, K.A. et al. Nature 413, 78–83 (2001).
Yamamoto, M. et al. Nature 420, 324–329 (2002).
Keating, S.E., Maloney, G.M., Moran, E.M. & Bowie, A.G. J. Biol. Chem. 282, 33435–33443 (2007).
Kanakaraj, P. et al. J. Exp. Med. 187, 2073–2079 (1998).
Suzuki, N. et al. Nature 416, 750–756 (2002).
Thomas, J.A. et al. J. Immunol. 163, 978–984 (1999).
Hanks, S.K. & Hunter, T. FASEB J. 9, 576–596 (1995).
Windheim, M., Stafford, M., Peggie, M. & Cohen, P. Mol. Cell. Biol. 28, 1783–1791 (2008).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Meylan, E., Tschopp, J. IRAK2 takes its place in TLR signaling. Nat Immunol 9, 581–582 (2008). https://doi.org/10.1038/ni0608-581
Issue Date:
DOI: https://doi.org/10.1038/ni0608-581
This article is cited by
-
IRAK2 and TLR10 confer risk of Hashimoto’s disease: a genetic association study based on the Han Chinese population
Journal of Human Genetics (2019)
-
Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules
Scientific Reports (2018)
-
Toll-like receptors: promising therapeutic targets for inflammatory diseases
Archives of Pharmacal Research (2016)
-
The extract of Tamarindus indica L. suppresses IKKβ activity and NF-κB-dependent lymphoblastoid cell line survival
Molecular & Cellular Toxicology (2013)
-
The kinome of Phytophthora infestans reveals oomycete-specific innovations and links to other taxonomic groups
BMC Genomics (2010)