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DC-SIGN 'AIDS' HIV immune evasion and infection

Human immunodeficiency virus uses many signaling pathways and cell surface receptors to infect cells. New work emphasizes the many functions of the lectin DC-SIGN expressed in dendritic cells.

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Figure 1: HIV-1 signals through various receptors at different cellular locations and at different stages in its replication cycle.

Kim Caesar

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Cunningham, A., Harman, A. & Donaghy, H. DC-SIGN 'AIDS' HIV immune evasion and infection. Nat Immunol 8, 556–558 (2007). https://doi.org/10.1038/ni0607-556

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