Hoffmann, J. Modifications of the haemogramme of larval and adult grasshoppers (Locusta migratoria) after selective X-irradiations of the hemocytopoietic tissue. J. Insect Physiol. 18, 1639–1652 (1972).
Steiner, H. et al. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292, 246–248 (1981).
Dimarcq, J.L. et al. Insect immunity. Purification and characterization of a family of novel inducible antibacterial proteins from immunized larvae of the dipteran Phormia terranovae and complete amino-acid sequence of the predominant member, diptericin A. Eur. J. Biochem. 171, 17–22 (1988).
Engstrom, Y. et al. kB-like motifs regulate the induction of immune genes in Drosophila. J. Mol. Biol. 232, 327–333 (1993).
Kappler, C. et al. Insect immunity. Two 17bp repeats nesting a kB-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila. EMBO J. 12, 1561–1568 (1993).
Belvin, M.P. & Anderson, K.V. A conserved signaling pathway: the Drosophila toll-dorsal pathway. Annu. Rev. Cell Dev. Biol. 12, 393–416 (1996).
Reichhart, J. et al. Expression and nuclear translocation of the rel/NF-kB-related morphogen dorsal during the immune response of Drosophila. C.R. Acad. Sci. (Paris) 316, 1218–1224 (1993).
Lemaitre, B. et al. A recessive mutation, immune deficiency (IMD), defines two distinct control pathways in the Drosophila host defense. Proc. Natl. Acad. Sci. USA 92, 9465–9469 (1995).
Fehlbaum, P. et al. Insect immunity: septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides. J. Biol. Chem. 269, 33159–33163 (1994).
Lemaitre, B. et al. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973–983 (1996).
Medzhitov, R., Preston-Hurlburt, P. & Janeway, C.A. Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394–397 (1997).
Rock, F.L. et al. A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. USA 95, 588–593 (1998).
Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085–2088 (1998).
Takeuchi, O. et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443–451 (1999).
Tauszig-Delamasure, S. et al. Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections. Nat. Immunol. 3, 91–97 (2002).
Levashina, E.A. et al. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Science 285, 1917–1919 (1999).
Weber, A.N. et al. Binding of the Drosophila cytokine Spatzle to Toll is direct and establishes signaling. Nat. Immunol. 4, 794–800 (2003).
Michel, T. et al. Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature 414, 756–759 (2001).
Royet, J. & Dziarski, R. Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences. Nat. Rev. Microbiol. 5, 264–277 (2007).
Gottar, M. et al. Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors. Cell 127, 1425–1437 (2006).