The integrated stress response is a complex signaling pathway that regulates myriad cell processes, including protein translation, depending on the stress conditions. Primed CD4+ T helper cells may use this response system to optimize cytokine expression.
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Murphy, K. Stress management for T helper differentiation. Nat Immunol 7, 553–555 (2006). https://doi.org/10.1038/ni0606-553
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DOI: https://doi.org/10.1038/ni0606-553