Human caspase-12, unlike that found in the mouse, is not involved in apoptosis and thus its physiological function is unclear. However, a unique polymorphism of human caspase-12 has demonstrated its importance in innate immunity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Egen, J.G., Kuhns, M.S. & Allison, J.P. Nat. Immunol. 3, 611–618 (2002).
Alexander, W.S. & Hilton, D.J. Annu. Rev. Immunol. 22, 503–529 (2004).
Kobayashi, K. et al. Cell 110, 191–202 (2002).
Pasare, C. & Medzhitov, R. Curr. Opin. Immunol. 15, 677–682 (2003).
Inohara, N. & Nunez, G. Nat. Rev. Immunol. 3, 371–382 (2003).
Saleh, M. et al. Nature 429, 75–79 (2004).
Earnshaw, W.C., Martins, L.M. & Kaufmann, S.H. Annu. Rev. Biochem. 68, 383–424 (1999).
Martinon, F., Burns, K. & Tschopp, J. Mol. Cell 10, 417–426 (2002).
Nakagawa, T. et al. Nature 403, 98–103 (2000).
Pasparakis, M., Alexopoulou, L., Episkopou, V. & Kollias, G. J. Exp. Med. 184, 1397–1411 (1996).
Fisher, C.J., Jr. et al. N. Engl. J. Med. 334, 1697–1702 (1996).
Abraham, E. et al. Crit. Care Med. 29, 503–510 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Winoto, A. Cutting into innate immunity. Nat Immunol 5, 563–564 (2004). https://doi.org/10.1038/ni0604-563
Issue Date:
DOI: https://doi.org/10.1038/ni0604-563