Nondeletional pathways for the development of autoreactive thymocytes

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Conventional wisdom holds that autoreactive thymocytes always undergo negative selection. This paradigm should be reassessed in light of evidence showing that alternative T cell lineages can develop in certain autoreactive conditions.

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Figure 1: Nondeletional pathways for the development of autoreactive thymocytes.

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Bendelac, A. Nondeletional pathways for the development of autoreactive thymocytes. Nat Immunol 5, 557–558 (2004) doi:10.1038/ni0604-557

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