Overexpression studies suggest that SOCS3 is a pleiotropic negative regulator of cytokines. The generation of Socs3−/− mice indicates that SOCS3 actually functions in a remarkably specific manner.
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Johnston, J., O'Shea, J. Matching SOCS with function. Nat Immunol 4, 507–509 (2003). https://doi.org/10.1038/ni0603-507
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DOI: https://doi.org/10.1038/ni0603-507