The α-defensins from Paneth cells in intestinal crypts need processing to be fully functional. Unlike for mice, the cleaving enzyme for human HD5 turns out to be trypsin.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ghosh, D. et al. Nature Immunol. 3 583–590 (2002).
Zasloff, M. Nature 415, 389–395 (2002).
Ouellette, A.J. & Bevins, C.L. Inflamm. Bowel Dis. 7, 43–50 (2001).
O'Neil, D.A. et al. J. Immunol. 163, 6718–6724 (1999).
Ayabe, T. et al. Nature Immunol. 1, 113–118 (2000).
Porter, E.M., Bevins, C.L., Ghosh, D. & Ganz, T. Cell. Mol. Life Sci. 58, 1–15 (2001).
Ganz, T. & Lehrer, R.I. Curr Opin. Hematol. 4, 53–58 (1997).
Wilson, C.L. et al. Science 286, 113–117 (1999).
Kim, H.S. et al. J. Immunol 165, 3268–3274 (2000).
Kong, W. et al. Proc. Natl. Acad. Sci. USA 94, 8884–8889 (1997)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zasloff, M. Trypsin, for the defense. Nat Immunol 3, 508–510 (2002). https://doi.org/10.1038/ni0602-508
Issue Date:
DOI: https://doi.org/10.1038/ni0602-508