Multiple error-prone DNA polymerase appear to contribute to immunoglobulin somatic hypermutation. Genetic and biochemical data now indicate that DNA polymerase η may be responsible for the generation of some of the strand-biased hotspot A mutations in the immunoglobulin loci.
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References
Storb, U. Curr. Opin. Immunol. 8, 206–214 (1996).
Liu, Y., Johnson, G., Gordon, J. & MacLennan, I. Immunol. Today 13, 17–21 (1992).
Rogozin, I. B., Pavlov, Y. I., Bebenek, K., Matsuda, T. & Kunkel, T. A. Nature Immunol. 2, 530–536 (2001).
Zeng, X. et al. Nature Immunol. 2, 537–541 (2001).
Zan, H. et al. Immunity 14, 643–653 (2001).
Betz, A. et al. Cell 77, 239–248 (1994).
Storb, U. et al. Cold Spring Harb. Symp. Quant. Biol. 64, 227–234 (1999).
Papavasiliou, F. N. & Schatz, D. G. Nature 408, 216–221 (2000).
Bross, L. et al. Immunity 13, 589–597 (2000).
Esposito, G. et al. Proc. Natl Acad. Sci. USA 97, 1166–1171 (2000).
Goodman, M. F. & Tippin, B. Curr. Opin. Genet. Dev. 10, 162–168 (2000).
Tissier, A., McDonald, J. P., Frank, E. G. & Woodgate, R. Genes Dev. 14, 1642–1650 (2000).
Shapiro, G., Aviszus, K., Ikle, D. & Wysocki, L. J. Immunol. 163, 259–268 (1999).
Betz, A. G., Rada, C., Pannel, R., Milstein, C. & Neuberger, M. Proc. Natl Acad. Sci. USA 90, 2385–2388 (1993).
Storb, U. et al. Curr. Top. Microbiol. Immunol. 229, 11–19 (1998).
Ohashi, E. et al. J. Biol. Chem. 275, 39678–39684 (2000).
Muramatsu, M. et al. Cell 102, 553–563 (2000).
Revy, P. et al. Cell 102, 565–575 (2000).
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Storb, U. DNA polymerases in immunity: profiting from errors. Nat Immunol 2, 484–485 (2001). https://doi.org/10.1038/88673
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DOI: https://doi.org/10.1038/88673
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