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Crohn's disease-associated Nod2 mutants reduce IL10 transcription

The 3020insC mutation in Nod2 is associated with Crohn's disease, but how it influences disease pathogenesis is unknown. A new study shows that the 3020insC mutant protein fails to activate a key transcription factor that drives interleukin 10 expression, resulting in reduced production of this anti-inflammatory cytokine.

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Figure 1: Reduced production of IL-10 in cells expressing Crohn's disease–associated mutations in Nod2.

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Philpott, D., Girardin, S. Crohn's disease-associated Nod2 mutants reduce IL10 transcription. Nat Immunol 10, 455–457 (2009). https://doi.org/10.1038/ni0509-455

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  • DOI: https://doi.org/10.1038/ni0509-455

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