Self-reactive B cells are subject to several mechanisms to ensure self-tolerance. The epithelium-derived cytokine TSLP acts to regulate B cell tolerance by targeting B cell precursors rather than mature B cells.
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Allman, D., Northrup, D. Giving B cell tolerance the 'TSLiP'. Nat Immunol 8, 481–483 (2007). https://doi.org/10.1038/ni0507-481
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DOI: https://doi.org/10.1038/ni0507-481
