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Epithelial NF-κB maintains host gut microflora homeostasis

Epithelial NF-κB preserves the integrity of the gut epithelial barrier and coordinates the antimicrobial actions of the innate and adaptive immune systems. Deficiency in or hyperactivation of this transcription factor results in chronic inflammatory bowel disease.

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Figure 1: Possible mechanisms of how NF-κB activation or activation failure affects host-microflora interactions in the gut.

Kim Caesar

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Ben-Neriah, Y., Schmidt-Supprian, M. Epithelial NF-κB maintains host gut microflora homeostasis. Nat Immunol 8, 479–481 (2007). https://doi.org/10.1038/ni0507-479

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