The mechanisms that enforce T cell quiescence are incompletely understood. Slfn2 has now been identified as another participant in this process, functioning as a critical regulator of T cell– and monocyte-mediated immunity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Berger, M. et al. Nat. Immunol. 11, 335–343 (2010).
Modiano, J.F., Johnson, L.D. & Bellgrau, D. Immunol. Res. 41, 137–153 (2008).
Tzachanis, D., Lafuente, E.M., Li, L. & Boussiotis, V.A. Leuk. Lymphoma 45, 1959–1967 (2004).
Feske, S., Giltnane, J., Dolmetsch, R., Staudt, L.M. & Rao, A. Nat. Immunol. 2, 316–324 (2001).
Glynne, R., Ghandour, G., Rayner, J., Mack, D.H. & Goodnow, C.C. Immunol. Rev. 176, 216–246 (2000).
Tzachanis, D. & Boussiotis, V.A. Cell Cycle 8, 1019–1025 (2009).
Kuo, C.T., Veselits, M.L. & Leiden, J.M. Science 277, 1986–1990 (1997).
Schwarz, D.A., Katayama, C.D. & Hedrick, S.M. Immunity 9, 657–668 (1998).
Condamine, T. et al. J. Leukoc. Biol. published online, doi:10.1189/jlb.0609410 (8 December 2009).
Sohn, W.J. et al. Mol. Immunol. 44, 3273–3282 (2007).
Gubser, C. et al. J. Gen. Virol. 88, 1667–1676 (2007).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Horton, M., Powell, J. Quieting T cells with Slfn2. Nat Immunol 11, 281–282 (2010). https://doi.org/10.1038/ni0410-281
Issue Date:
DOI: https://doi.org/10.1038/ni0410-281