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High specificity, not degeneracy, allows T cell alloresponses

Nature Immunology volume 8, pages 335–337 (2007)Cite this article

Alloreactive T cell responses are considered the product of 'degenerate' recognition by T cells of many different complexes of peptide and major histocompatibility complex. New work shows instead that T cell receptor alloresponses are highly 'polyspecific' for such complexes.

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Figure 1: Possible modes of TCR interaction with different endogenous peptides bound to allogeneic MHC in the course of an alloreactive response.

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Authors and Affiliations

  1. Janko Nikolich-Žugich is with the Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon 97006, USA. nikolich@ohsu.edu,

    Janko Nikolich-Žugich

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  1. Janko Nikolich-Žugich
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Nikolich-Žugich, J. High specificity, not degeneracy, allows T cell alloresponses. Nat Immunol 8, 335–337 (2007). https://doi.org/10.1038/ni0407-335

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