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TRIMming HIV-1's mainsail

HIV-1 is unable to infect cells from most nonhuman primates. In a recent Nature paper, a cellular protein of monkey cells, TRIM5α, was shown to be responsible for this inhibition.

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Figure 1: TRIM5α-mediated lentivirus restriction.

K.R.

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Stevenson, M. TRIMming HIV-1's mainsail. Nat Immunol 5, 355–356 (2004). https://doi.org/10.1038/ni0404-355

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