Crawling and INTEGRating apical cues

Leukocytes are arrested on endothelial cells before moving through vessel intercellular junctions. The identification of another β2 integrin–dependent step may provide insights into the events and signals required for transmigration.

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Figure 1: Monocyte locomotion on vascular endothelium: directional transport to the site of transmigration (TEM) and an 'educational' process for essential leukocyte and endothelial cell polarization.

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References

  1. 1

    Muller, W.A. Trends Immunol. 24, 326–334 (2003).

  2. 2

    Schenkel, A.R., Mamdouh, Z. & Muller, W.A. Nat. Immunol. 5, 393–400 (2004).

  3. 3

    Springer, T.A. Cell 76, 301–314 (1994).

  4. 4

    Worthylake, R.A., Lemoine, S., Watson, J.M. & Burridge, K. J. Cell. Biol. 154, 147–160 (2001).

  5. 5

    Vicente-Manzanares, M. & Sanchez-Madrid, F. Nat. Rev. Immunol. 4, 1–14 (2004).

  6. 6

    Smith, A., Bracke, M., Leitinger, B., Porter, J.C. & Hogg, N. J. Cell Sci. 116, 3123–3133 (2003).

  7. 7

    Mamdouh, Z., Chen, X., Pierini, L.M., Maxfield, F.R. & Muller, W.A. Nature 421, 748–753 (2003).

  8. 8

    Barreiro, O. et al. J. Cell. Biol. 157, 1233–1245 (2002).

  9. 9

    Cinamon, G., Shinder, V. & Alon, R. Nat. Immunol. 2, 515–522 (2001).

  10. 10

    Weber, C. & Springer, T.A. J. Immunol. 161, 6825–6834 (1998).

  11. 11

    Marschel, P. & Schmid-Schonbein, G.W. Ann. Biomed. Eng. 30, 333–343 (2002).

  12. 12

    Gopalan, P.K. et al. J. Leukoc. Biol. 68, 47–57 (2000).

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Alon, R., Luscinskas, F. Crawling and INTEGRating apical cues. Nat Immunol 5, 351–353 (2004). https://doi.org/10.1038/ni0404-351

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