Proteases, proteases and proteases for presentation

Peptide epitope generation for MHC class I presentation is normally dependent upon proteasome activity. Yet this pathway fails to generate critical HIV epitopes. Instead, the protease TPPII is required for this activity.

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Figure 1: Proteases involved in the processing of HIV epitopes.

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Correspondence to Jacques Neefjes.

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Herberts, C., Reits, E. & Neefjes, J. Proteases, proteases and proteases for presentation. Nat Immunol 4, 306–308 (2003). https://doi.org/10.1038/ni0403-306

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