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Revival of the autoantibody model in rheumatoid arthritis

Nature Immunology volume 3, pages 342344 (2002) | Download Citation

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Abstract

New evidence revives the old idea that B cells are the principal effectors in rheumatoid arthritis: autoantibodies against a ubiquitous antigen cause joint-specific disease. The resolution of these conflicting hypotheses resides in the joint itself. “ (On-Ko-Chi-Shin) the new idea resides within the old.”

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Affiliations

  1. Department of Molecular Oncology, Osaka University Graduate School of Medicine. Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Osaka 565-0871, Japan. hirano@molonc.med.osaka-u.ac.jp

    • Toshio Hirano

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DOI

https://doi.org/10.1038/ni0402-342

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