Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

Multilineage development from adult bone marrow cells

The potential of hematopoietic stem cells to generate tissue-specific lineages varies with the criteria used to isolate such cells. New discoveries continue to refine our definition of what a hematopoietic stem cell is and what it can do.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Hypotheses to explain the generation of nonhematopoietic tissues from HSC-enriched populations.

References

  1. Verfaille, C. M. Nature Immunol. 3, 314–317 (2002).

    Article  Google Scholar 

  2. Orkin, S. H. & Zon, L. I. Nature Immunol. 3, 323–328 (2002).

    Article  CAS  Google Scholar 

  3. Geiger, H. & Van Zant, G. Nature Immunol. 3, 329–333 (2002).

    Article  CAS  Google Scholar 

  4. Morrison, S. J. Curr. Biol. 11, 7–9 (2001).

    Article  Google Scholar 

  5. Gussoni, E. et al. Nature 401, 390–394 (1999).

    CAS  PubMed  Google Scholar 

  6. Jackson, K. A. et al. J. Clin. Invest. 107, 1395–1402 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lagasse, E. et al. Nature Med. 6, 1229–1234 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Krause, D. S. et al. Cell 105, 369–377 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. Prockop, D. J. Science 276, 71–74 (1997).

    Article  CAS  PubMed  Google Scholar 

  10. Pittenger, M. F. et al. Science 284, 143–147 (1999).

    Article  CAS  PubMed  Google Scholar 

  11. Anderson, D. J., Gage, F. H. & Weissman, I. L. Nature Med. 4, 393–395 (2001).

    Article  Google Scholar 

  12. Campbell, K. H., McWhir, J. Ritchie, W. A. & Wilmut, I. Nature 380, 64–66 (1996).

    Article  CAS  PubMed  Google Scholar 

  13. Wakayama, T., Perry, A. C., Zuccotti, M., Johnson, K. R. & Yanagimachi, R. Nature 394, 369–374 (1998).

    Article  CAS  PubMed  Google Scholar 

  14. Surani, M. A. Nature 414, 122–128 (2001).

    Article  CAS  PubMed  Google Scholar 

  15. Wei, G., Schubiger, G., Harder, F. & Muller, A. M. Stem Cells 18, 409–414 (2000).

    Article  CAS  PubMed  Google Scholar 

  16. Blau, H. M., Brazelton, T. R. & Weimann, J. M. Cell 105, 829–841 (2001).

    Article  CAS  PubMed  Google Scholar 

  17. Hochedlinger, K. & Jaenisch, R. Nature 415, 1035–1038 (2002).

    Article  CAS  PubMed  Google Scholar 

  18. Bianco, P. & Robey, P. G. Nature 414, 118–121 (2001).

    Article  CAS  PubMed  Google Scholar 

  19. Weiss, P. Principles of Development (Holt and Co., New York, 1939).

    Google Scholar 

  20. Gollner, G. et al. Cytokine 11, 656–663 (1999).

    Article  CAS  PubMed  Google Scholar 

  21. Schmitt, R. M., Bruyns, E. & Snodgrass, H. R. Genes Dev. 5, 728–740 (1991).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

I thank E. Montecino-Rodgriguez, M. Teitell and J. Tidball for reading the manuscript and providing editorial suggestions.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dorshkind, K. Multilineage development from adult bone marrow cells. Nat Immunol 3, 311–313 (2002). https://doi.org/10.1038/ni0402-311

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0402-311

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing