Both activation and termination of transcription factor NF-κB signaling require ubiquitin modification of pathway components. The E3 ligase Itch teams up with the NF-κB inhibitor A20 to edit the composition of ubiquitin chains on the signaling adaptor RIP, thereby limiting inflammatory responses.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Fang, D. et al. Nat. Immunol. 3, 281–287 (2002).
Perry, W.L. et al. Nat. Genet. 18, 143–146 (1998).
Shembade, N. et al. Nat. Immunol. 9, 254–262 (2008).
Lin, A.E. & Mak, T.W. Curr. Opin. Immunol. 19, 665–673 (2007).
Adhikari, A., Xu, M. & Chen, Z.J. Oncogene 26, 3214–3226 (2007).
Wertz, I.E. et al. Nature 430, 694–699 (2004).
Shembade, N., Harhaj, N.S., Liebl, D.J. & Harhaj, E.W. EMBO J. 26, 3910–3922 (2007).
Lee, E.G. et al. Science 289, 2350–2354 (2000).
Zenz, R. et al. Nature 437, 369–375 (2005).
Heyninck, K. & Beyaert, R. Trends Biochem. Sci. 30, 1–4 (2005).
Heissmeyer, V. et al. Nat. Immunol. 5, 255–265 (2004).
Oeckinghaus, A. et al. EMBO J. 26, 4634–4645 (2007).
Macian, F. et al. Cell 109, 719–731 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Heissmeyer, V., Rao, A. Itching to end NF-κB. Nat Immunol 9, 227–229 (2008). https://doi.org/10.1038/ni0308-227
Issue Date:
DOI: https://doi.org/10.1038/ni0308-227
This article is cited by
-
A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks
Cellular and Molecular Life Sciences (2013)
-
RNF11, a new piece in the A20 puzzle
The EMBO Journal (2009)