Itching to end NF-κB

Both activation and termination of transcription factor NF-κB signaling require ubiquitin modification of pathway components. The E3 ligase Itch teams up with the NF-κB inhibitor A20 to edit the composition of ubiquitin chains on the signaling adaptor RIP, thereby limiting inflammatory responses.

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Figure 1: TNF signal transduction and termination by ubiquitin editing.

Katie Ris-Vicari

References

  1. 1

    Fang, D. et al. Nat. Immunol. 3, 281–287 (2002).

  2. 2

    Perry, W.L. et al. Nat. Genet. 18, 143–146 (1998).

  3. 3

    Shembade, N. et al. Nat. Immunol. 9, 254–262 (2008).

  4. 4

    Lin, A.E. & Mak, T.W. Curr. Opin. Immunol. 19, 665–673 (2007).

  5. 5

    Adhikari, A., Xu, M. & Chen, Z.J. Oncogene 26, 3214–3226 (2007).

  6. 6

    Wertz, I.E. et al. Nature 430, 694–699 (2004).

  7. 7

    Shembade, N., Harhaj, N.S., Liebl, D.J. & Harhaj, E.W. EMBO J. 26, 3910–3922 (2007).

  8. 8

    Lee, E.G. et al. Science 289, 2350–2354 (2000).

  9. 9

    Zenz, R. et al. Nature 437, 369–375 (2005).

  10. 10

    Heyninck, K. & Beyaert, R. Trends Biochem. Sci. 30, 1–4 (2005).

  11. 11

    Heissmeyer, V. et al. Nat. Immunol. 5, 255–265 (2004).

  12. 12

    Oeckinghaus, A. et al. EMBO J. 26, 4634–4645 (2007).

  13. 13

    Macian, F. et al. Cell 109, 719–731 (2002).

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Heissmeyer, V., Rao, A. Itching to end NF-κB. Nat Immunol 9, 227–229 (2008). https://doi.org/10.1038/ni0308-227

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