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Nef: out and in?

Lentiviral Nef protein has many functions in the evasion of host immune defenses. Another 'chink' in the host immune 'armor' has now been exposed by Nef's ability to inhibit immunoglobulin class switching.

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References

  1. 1

    Kestler, H.W. III, et al. Cell 65, 651–662 (1991).

  2. 2

    Peterlin, B.M. & Trono, D. Nat. Rev. Immunol. 3, 97–107 (2003).

  3. 3

    Qiao, X. et al. Nat. Immunol. 7, 302–310 (2006).

  4. 4

    Das, S.R. & Jameel, S. Indian J. Med. Res. 121, 315–332 (2005).

  5. 5

    Geyer, M., Fackler, O.T. & Peterlin, B.M. EMBO Rep. 2, 580–585 (2001).

  6. 6

    Choi, J. et al. J. Virol. 79, 264–276 (2005).

  7. 7

    Costa, L.J. et al. J. Virol. 78, 5311–5323 (2004).

  8. 8

    Swingler, S. et al. Nature 424, 213–219 (2003).

  9. 9

    Xu, X.N. et al. J. Exp. Med. 186, 7–16 (1997).

  10. 10

    Schacker, T. et al. J. Infect. Dis. 183, 555–562 (2001).

  11. 11

    Stumptner-Cuvelette, P. et al. Mol. Biol. Cell 14, 4857–4870 (2003).

  12. 12

    Moir, S. et al. Proc. Natl. Acad. Sci. USA 98, 10362–10367 (2001).

  13. 13

    Harrer, E. et al. Antivir. Ther. 10, 285–300 (2005).

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Figure 1: Nef exits infected cells, enters B cells and suppresses CSR.

Katie Ris